Suspected piperacillin-tazobactam induced nephrotoxicity in the pediatric oncology population.

نویسندگان

  • Jennifer A Pratt
  • Melisa K Stricherz
  • Priya S Verghese
  • Michael J Burke
چکیده

Neutropenic fever is a common complication of myelosuppressive therapy in pediatric oncology patients. Piperacillin-tazobactam (PIP/TAZO) is a broad spectrum antibiotic used for empiric treatment of neutropenic fever. We describe four cases of suspected PIP/TAZO induced nephrotoxicity occurring in children with pediatric malignancies admitted to the hospital and treated for fever ± neutropenia. All patients exhibited acute renal injury shortly after PIP/TAZO administration with one of these cases having biopsy evidence of acute interstitial nephritis. These findings are suggestive of PIP/TAZO induced nephrotoxicity in pediatric oncology patients with fever ± neutropenia and that PIP/TAZO should be used judiciously in this population.

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عنوان ژورنال:
  • Pediatric blood & cancer

دوره 61 2  شماره 

صفحات  -

تاریخ انتشار 2014